PRDM2 was identified as a differentially expressed candidate, and the molecular consequences of its repression were assessed by measuring H3K9 mono-methylation. These drugs are either cholinesterase inhibitors donepezil, rivastigmine, galantamine or NMDA receptor antagonists memantine.
Background: Neuroinflammation and abnormal immune responses have been implicated in schizophrenia. Thus, it is reasonable to evaluate whether important precursors to diabetes risk, such as hepatic insulin resistance, can be linked to increases in adiposity occurring during antipsychotic treatment.
In humans, we determined if risk variants of FKBP5 were associated with abnormal fear extinction trajectories.
Background: Cholinesterase inhibitors ChEIs remain the therapeutic mainstay for patients with dementia of the Alzheimer's type DAT despite their small effect size, dose-limiting adverse events AEs , and the need for prolonged dose titration.
Immunohistochemical analysis indicated that this occurred in neurons. On the contrary, multiple schizophrenia-related behavioral abnormalities emerged with a delayed onset in adulthood but not adolescence. Analysis of firing patterns in the OFC during grooming induction is ongoing.
Over the past decade, highly selective positive allosteric modulators PAMs of the metabotropic glutamate receptor subtype 5 mGlu5 have emerged as a promising new approach for improving cognitive function in schizophrenia and other non-degenerative CNS disorders.
Keywords: machine learning, neuroimaging, cortical thickness, Trajectories.