Founder and director Rainmakers Worldwide. We need to develop a better understanding of the risk of vCJD infection to both the individual and to the population and aim to address this by taking research and surveillance forward in a fully integrated manner to assess the risks of vCJD to public health.
It has been long established that inbred mouse lines with identical PrP alleles and indistinguishable levels of PrP c expression have distinct incubation periods related to the effect of a number of modifier genes.
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Clare Elizabeth Hayward, DL. P Altered dynamics of membrane microdomain distribution in chronically prion-infected cells. Professor Abigail Gregory. Norwich, Norfolk.
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We are now undertaking structural characterization of prion assemblies and comparing these to the structure of non-infectious PrP fibrils generated from recombinant PrP. In such a structure the amino acid side chains would all be surface exposed and would be expected to react in a similar fashion.
Similar unexpected phenotypes, which are transmissible and can induce a vCJD phenotype after secondary transmission, were also observed but in lower proportion when soluble brain infectivity was intravenously administered in the same models.
A central hypothesis is that misfolded protein accumulation, spread and distribution predict regions of neurodegeneration. Shireoaks, Nottinghamshire. Norwich, Norfolk.