Forthcoming issues. Revision Received:. It remains unclear, however, whether changes in this protein domain have led to novel interacting partners and therefore novel functions. CENP-A inheritance through meiosis. Naturally occurring differences in CENH3 affect chromosome segregation in zygotic mitosis of hybrids.
Prenatal Diagnosis. Roles of centromeres in meiosis-specific processes. About years after their initial description, centromeres still hold many secrets. This spindle must function with the highest of fidelity and yet its assembly is unusually achieved in the absence of conventional centrosomes and with minimal influence of chromatin.
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Taken together, the meiosis-specific phenomena, such as centromere drive, shape the function and potentially influence the structure of centromeric proteins. Fusion of the male and females gametes forms the diploid zygote, which develops into the sporophyte. All Issues. These factors work at multiple levels to inhibit crossovers the process that produces haploid sex cells in Bury the centromere, by preventing both meiotic double stranded breaks DSBs as well as inter-homolog repair [ 2122 ].
In fact, centromere pairing is stable in mutants that affect centromere coupling [ 14 ]. Centromeres have been shown to be primary initiation sites of synapsis in several species Figure 1 B [ 15—18 ].
Male gametogenesis. Wenda ; The polymerization of Zip1 at the centromere then starts synapsis, which spreads along the chromosome axes [ 15 ]. A Overview of meiotic stages, highlighting the roles of centromeres red squares in chromosome pairing and recombination, and in segregation of homologous chromosomes and sister chromatids.
The authors declare that there are no competing interests associated with the manuscript. These observations were confirmed by Ravi and colleagues, who showed that replacing the endogenous N-terminal tail of A.